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#SarsCoV2

37 posts28 participants6 posts today
Public
Tom Kindlon

Five years of Long Covid

Links:
NBC News
nbcnews.com/health/health-news

US News and World Report:
usnews.com/opinion/articles/20

Rolling Stone:
rollingstone.com/culture/cultu

s4me.info/threads/news-from-th

From the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Five years of Long Covid The five year anniversary of the start the COVID-19 pandemic has prompted several media outlets to publish stories on Long Covid. NBC News: 5 years later, long Covid is still a medical mystery: What scientists have learned US News and World Report: 5 Years Since the COVID-19 Pandemic, Millions Like Me Are Still Sick Rolling Stone: Five Years of Pain, Fatigue, and Gaslighting: Life With Long Covid More stories in this Thread
Public
Broadwaybabyto

It’s International Long Covid Awareness Day, and my latest article looks at the reasons why people believe they don’t know anyone with Long Covid.

We desperately need increased visibility into this debilitating chronic illness so that we can raise awareness and fund treatments, mitigations and cures.

Anyone can get Long Covid. It’s not limited to ‘only the vulnerable’ or those who had a severe initial infection.

This disease does not discriminate. Even people with asymptomatic initial infections have found themselves disabled by Long Covid.

It’s time we start processing the trauma of the pandemic and stop living in denial.

We are in the middle of a mass disabling event, and the longer it takes us to admit that, the more people will be harmed.

Let’s spread the word that the only way to avoid Long Covid is to avoid getting Covid in the first place.

Wear a mask. Stay home when sick. Clean and ventilate the air.

When we all agree to care about the air we share, we can begin to bring about real change.

disabledginger.com/p/i-dont-kn

The Disabled Ginger · I Don't Know Anyone With Long CovidBy Broadwaybabyto
#longcovid#longcovidawarenessday#covidisairborne
Public *
Eric's Risk Assessment

Ensitrelvir Prevents #COVID19 Infection as Post Exposure Prophylaxis

> Japan-based Shionogi presented results for its investigational antiviral, ensitrelvir, that demonstrated a 67% reduction in the risk of developing COVID-19 in uninfected individuals treated after exposure, compared to a placebo at day 10

contagionlive.com/view/ensitre

ContagionLive · Ensitrelvir Prevents COVID-19 Infection as Post Exposure ProphylaxisBy John Parkinson
#sars2#sarscov2#antiviral
Public *
Ms. Opossum graphs COVID data.

UPDATED: #Quebec #SARSCoV2 variants.

⚠️ Only 50 & 20 samples for weeks of 2/23, 3/2 ⚠️

Of the 20,
XEC.*: 45% (⬆️ 18%; ⬇️ 29.8%)
LP.8.1.*: 20% (⬆️ 6%; ⬆️ 4.3%)
KP.3.1.1.*: 5% (⬇️ 22%; ⬇️ 23.4%)
LF.7.7.2: 25% (⬇️ 28%; ⬆️ 23.4%)

ratnegative.tumblr.com/QCVaria #COVID19

----------

Of the samples collected in Quebec on these weeks, the prevalence of significant variants/lineages are as follows:

- 3/2 - 3/8 - (20 samples; no threshold)
• XEC.* (incl. XEC.5, ".9, ".11): 45%
• JN.1.11.1.*: 25%
→ LP.8.1.*: (incl. LP.8.1.1): 20%
→ KP.3.* (only MC.10.1): 5%
• LF.7.* (incl. LF.7.7.2): 30%
→ LF.7.7.2: 25%

- 2/23 - 3/1 - (50 samples; 4% threshold)
• XEC.* (incl. XEC.2, ".9, ".13): 18%
• JN.1.11.1.*: 38%
→ LP.8.1.* (only LP.8.1.1): 6%
→ KP.3.* (only KP.3.1.*, ".3.3.5): 32%
→ KP.3.1.1.* (incl. MC.1.2, ".10.1.*, ".11, ".13.2.1, "28.1.1): 22%
→ MC.1.* (only MC.1.2): 10%
• LF.7.* (incl. LF.7.1, ".7.2.1, ".7.7.2): 40%
→ LF.7.7.2: 28%

X.X.* in text = X.X & descendants.
X.X.* in graph = all descendants of X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

Public
Jiko Desu

German spy agency believed CoVid-19 likely started in a laboratory in Wuhan.

The widely accepted theory is that Covid-19 emerged in bats and then jumped to humans, most likely through another animal, or "intermediary host."

As time worn on, scientists have not found a virus in either bats or another animal that matches the genetic make-up of Covid-19, leading some to doubt the theory.

#Pandemic #CoVid19 #Asian #Health #Virus #PublicHealth #SARSCov2

bbc.com/news/articles/cz7vypq3

Four security guards wearing face masks, whose figures are slightly blurred because of the camera's focus, stand in the foreground of the picture. Behind them is the Wuhan Institute of Virology with signs in English and Mandarin
www.bbc.comGerman spy agency 'believed Covid likely started in lab'China denies German media reports of an assessment carried out by spying agency BND in 2020 supporting the theory.
Public
tagesschau

Corona-Infektionen: Rätsel um PIMS-Erkrankungen bei Kindern gelöst

Die Ursache für das rätselhafte Entzündungssyndrom PIMS als Folge einer Coronainfektion bei Kindern war lange unklar. Jetzt haben Forschende einen Zusammenhang mit einem anderen Virus gefunden. Von Nina Kunze.

➡️ tagesschau.de/wissen/gesundhei

#Corona#PIMS#Kindergesundheit
Public
Dr Emma Hodcroft :verified:

Great article from Ewen Callaway in Nature about how #SARSCoV2 has helped us better understand viruses - including the areas where we still have much to learn.

“This was one of the first times where evolutionary biology became an applied science” says @jbloom_lab

nature.com/articles/d41586-025

www.nature.comFour ways COVID changed virology: lessons from the most sequenced virus of all timeAfter 150,000 articles and 17 million genome sequences, what has science taught us about SARS-CoV-2?
Public *
Charité Berlin

‼️ Cause of post-#COVID inflammatory shock in children identified: Reactivation of the Epstein-Barr virus appears to cause the rare condition #MISC. The findings, uncovered by a team from #CharitéBerlin & the DRFZ, have now been published in #Nature.

💡 These insights open the door to new treatment methods, potentially not limited to MIS-C.

👉 charite.de/en/service/press_re

#CharitéPaper #Science #Research #Medicine #EBV #PIMS #SARSCoV2 #COVID19 #corona
@nature.portfolio

Child in bed (from behind), cuddling with a teddy bear. Text: "Cause of post-COVID inflammatory schock in children identified" © Charité
Public *
Broadwaybabyto

Today marks the five year anniversary of Covid being declared a pandemic. Some things I want people to remember:

The threat is not gone. People are still dying and becoming disabled every single day

COVID is airborne. It’s always been airborne. Droplet transmission was pushed incorrectly & then doubled down on for economic reasons. If governments admit it’s airborne, they have to spend money upgrading air quality and providing respirators etc.

The only way to avoid Long Covid is to not get Covid.

A well fitted respirator like an N95 offers excellent personal protection

Mask mandates belong in healthcare

If you’re not masking for your patient, you’re abdicating your responsibility to do no harm

It costs nothing to open a window and it will improve ventilation and reduce odds of viral spread. Air purifiers work well too

COVID is a social justice issue. Masks, tests, air filters, paid time off… these things all cost money. The disease disproportionately impacts those who are most vulnerable and multiple marginalized

Repeat infections don’t make you stronger. They don’t give you immunity. They actually harm your brain, heart and immune system. They’re also NOT inevitable

Kids are harmed by COVID too. They need the adults to protect them. We need clean in schools and on school buses

We went “back to normal” for capitalism. It wasn’t because it was safe. It wasn’t because there was a cure. Governments and those in power Are willing to sacrifice us to keep end stage capitalism afloat a little longer

Repeat infections are NOT inevitable. We can still curb the spread. We don’t have to accept constant sickness and disability as our new normal.

May we be in a much better place five years from now than we are today.

If you know someone suffering from Long Covid, reach out to them. Ask them how you can support them. Remind them they’ve not been forgotten. Wear a mask for them. They are counting on you.

#covidisairborne#covidisnotover#sarscov2
Replied in thread
Public *
datum (n=1)

@c_9 That IS really exciting!

➡️ prophylactic: "1500-fold reduction in viral load compared with the untreated control" and
➡️ therapeutic: "mean viral load was ~110-fold lower"
(in live mice)

"RBD-specific nAbs have been shown to be the most potent and have exclusively been deployed as approved therapeutics. However, with the emergence of the highly divergent Omicron variants [...] the efficacy of most RBD-specific nAb clinical treatments diminished, leading to their withdrawal from the market"

"several research groups, including ours, have developed multivalent constructs such as bispecific antibodies (bsAbs). These bsAbs feature two different antigen-binding fragments (Fabs) targeting nonoverlapping spike protein epitopes"

Two of the developed bsAbs "retained potent in vitro neutralization activity against all Omicron variants tested"

They observed "infrequent escape mutations in the NTD in response to [bsAbs]"

"the epitope targeted by C1596-like mAbs is under minimal selective pressure and that bsAbs using C1596 as an anchoring modality, such as CoV2-biRN5, may be resilient to circulating strains."

"the versatility of this platform extends beyond SARS-CoV-2, with potential applications against other viral proteins, including those in influenza or HIV. By leveraging broadly binding antibodies to tether other antibodies or inhibitors, these bispecific modalities offer a promising next-generation prophylactic or therapeutic option"

@ducky this seems like it'd be of interest to you too

#SARSCoV2#CovidIsNotOver#COVID19
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